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Bioelectromagnetic Medicine – Chapter 44 Unabridged Version
Cranial Electrotherapy Stimulation for Anxiety, Depression, Insomnia, Cognitive Dysfunction, and Pain: A Review and Meta-Analyses

Daniel L. Kirsch, Ph.D., D.A.A.P.M., F.A.I.S. and Ray B. Smith, Ph.D.
 

Table 1. List and description of CES studies of depression

Author

Treatment
Parameters

Primary
Diagnosis

 

Blinding

 

Study
Design

Outcome
Measure

Subject

Therapist

Assessor

Bianco
(14)

45 min Daily,
6-14 Days

Alcoholism

Yes

Yes

Yes

Double
Blind

Hamilton, and Beck
Depression Scales

Feighner
(82)

30 min Daily,
M-F, 14 Days

Psychiatric
Inpatients

Yes

Yes

Yes

Crossover

Zung SRDS (a)

Frankel
(17)

45 min Daily,M-F, 15
Days, 15 Hz
& 100 Hz
Groups
Combined

Insomnia

Yes

Yes

Yes

Crossover,
100Hz/15Hz

Zung SRDS

Hearst
(83)

30 min Daily,5 Days

Insomnia

Yes

Yes

Yes

Crossover

NIMH Self Rated

Symptom Scale

Krupistsky

(84)

30 min Daily,

M-F, 20

Days

Alcoholics

Yes

Yes

Yes

Double

Blind

Zung, SRDS, MMPI

Depression Scale

Levitt (85)

30 min Daily,

M-F, 10

Days

Psychiatric

Inpatients

Yes

Yes

Yes

Double

Blind

Clinical Rating

Scale

Smith (86)

45 min Daily,

M-Th, 12

Days

Closed Head

Injured

Yes

Yes

Yes

Double

Blind

POMS (b)

Marshall

(24)

30 min Daily,

M-F, 5 Days

Psychiatric

Inpatients

Yes

Yes

Yes

Double

Blind

DES+D II

Matteson

(16)

30-40 min

Daily, 14

Days

Graduate

Students

No

No

No

Open

Clinical

POMS

Tyers (64)

60 min Daily,

21 Days

Fibromyalgia

No

No

No

Open

Clinical

POMS

Tyers (65)

60 min Daily,

21 Days

Fibromylagia

No

No

No

Open

Clinical

POMS

Lichtbroun

(43)

60 min Daily,

21 Days

Fibromyalgia

Yes

Yes

Yes

Double

Blind

POMS

Kirsch (7)

Various,

Home Use

Diagnosed

Depression

No

No

No

Open

Clinical

Physician’s Rating

May (87)

60 min Daily,

25 Days

Addiction

No

No

No

Open

Clinical

Beck Depression

Scale, MAACL (c)

Moore

(42)

30 min Daily,

5 Days

Anxiety,

Insomnia,

Depression

Yes

Yes

Yes

Double

Blind,

Crossover

Beck’s Depression

Scale, Clinical

Ratings

Passini

(25)

30 min Daily,

M-F, 10

Days

Psychiatric

Inpatients

Yes

Yes

Yes

Double-

Blind

MAACL

Phillip (26)

30 min, 2x

Day, 5 Days

Psychiatric

Inpatient

Addicts

Yes

Yes

Yes

Double-

Blind

MADRS (d)

Rosenthal

(88)

30 min Daily,

5 Days

Psychiatric

Outpatients

Yes

Yes

Yes

Double-

blind

Crossover

Clinical Ratings,

Zung SRDS

Rosenthal

(12)

30 min Daily,

M-F, 5 to 8

Days

Psychiatric

Outpatients

No

No

No

Open

Clinical

Zung SRDS,

Clinical Ratings

Rosenthal

(18)

30 min Daily,

M-F, 5 to 10

Days

Psychiatric

Outpatients

No

No

No

Open

Clinical

Clinical Ratings,

Zung SRDS

Shealy

(89)

20 min Daily,

14 days

Chronic

Pain,

Depression

No

No

No

Open

Clinical

Serum

Neurochemicals

 

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Bioelectromagnetic Medicine• 2004

Used with permission of Electromedical Products International, Inc.

©2006 by
 

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Cranial Electrotherapy Stimulation for Anxiety, Depression, Insomnia, Cognitive Dysfunction, and Pain: A Review and Meta-Analyses