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Bioelectromagnetic Medicine – Chapter 44 Unabridged Version
Cranial Electrotherapy Stimulation for Anxiety, Depression, Insomnia, Cognitive Dysfunction, and Pain: A Review and Meta-Analyses

Daniel L. Kirsch, Ph.D., D.A.A.P.M., F.A.I.S. and Ray B. Smith, Ph.D.
 

Smith (13)

40 min Daily,

M-F, 15

Days

Inpatient

Alcoholics

Yes

No

Yes

Single Blind

POMS

Smith (11)

45 min Daily,

21 Days

ADHD

No

No

No

Open

Clinical

IPAT Depression

Scale

(a)  Zung’s Self Rating Depression Scale
(b)
  Profile of Mood States
(c)
  Multiple Affect Adjective Check List
(d)
  Montgomery and Asberg Depression Rating Scale

Table 2. Analysis of studies shown in Table 1

 

Number of Patients

 

 

 

Author

CES

Controls

Total

Statistic Reported

Results

Zr Score (a)

Bianco (14)

11

18

29

% Improvement

80% (b)

1.099

Feighner (82)

23

23

23

% Improvement Zung SRDS

17%

.172

% Improvement, Clinical Rating

Scale

26%

.266

Frankel (17)

17

17

17

% Improvement

0%

.000

Hearst (83)

14

14

28

% Improvement

73%

.929

Krupitsky (84)

10

10

20

% Improvement, Zung SRDS

23%

.234

% Improvement, MMPI

32%

.332

Levitt (85)

5

6

11

% Improvement

25%

.255

Smith (86)

10

11

21

% Improvement

30%

.310

Marshall (24)

20

20

40

% Improvement

0%

.000

Matteson (16)

32

22

54

% Improvement

34%

.354

Tyers (64)

20

 

20

% Improvement

35%

.365

Tyers (65)

60

 

60

% Improvement

26%

.266

Lichtbroun (43)

40

20

60

% Improvement

31%

.321

Kirsch (7)

69

 

69

Average % Improvement

71%

.887

May (87)

15

 

15

% Improvement, Beck DI

76%

.996

% Improvement, MAACL

77%

1.02

Moore (42)

17

17

17

% Improvement, Clinical Ass.

59%

.678

% Improvement, Self Rated

17%

.172

% Improvement, Beck DI

5%

.050

Passini (25)

30

30

60

% Improvement

24%

.245

Phillip (26)

10

11

21

% Improvement

0%

.000

Rosenthal (88)

11

11

22

% Improvement, Clin Rating

64%

.758

% Improvement, Zung SRDS

21%

.213

Rosenthal (12)

9

 

9

% Improvement, Clin Rating

38%

.400

% Improvement, Zung SRDS

29%

.299

Rosenthal (18)

12

6

18

% Improvement, Clin Rating

56%

.633

% Improvement, Zung SRDS

37%

.388

Shealy (89)

34

14

48

% Improvement

50%

.549

Smith (13)

36

36

72

% Improvement

67%

..881

Smith (11)

23

 

23

% Improvement

32%

.332

Total

826

306

1075

Mean

Mean Effect Size

N Weighted Effect Size

Heterogeneity X2 = 3.11,

Df= 31.

Standard Error of the Mean =

0.31

38%

.437

r = .41

r = .53

n.s.

(a)  From Fisher Tables of r to zr transformation (Edwards, 1964)
(b)
  Percent change equals r, from the binomial effect size distribution From Wolf, 1986, p33.

 

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Bioelectromagnetic Medicine• 2004

Used with permission of Electromedical Products International, Inc.

©2006 by
 

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Chronic Pain Relief Now.Com and Moeller Medical, LLC express no opinion with regard to representations made herein.  Chronic Pain Relief Now.Com and Moeller Medical, LLC support only those representations contained within the labeling of the Alpha-Stim® products.
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Cranial Electrotherapy Stimulation for Anxiety, Depression, Insomnia, Cognitive Dysfunction, and Pain: A Review and Meta-Analyses